Intralesional Mycobacterium w Vaccine Versus Cryotherapy in Treatment of Refractory Extragenital Warts

Author:

Dhakar Ashok K.1,Dogra Sunil1,Vinay Keshavamurthy1,Sarangal Rishu1,Kanwar Amrinder J.1,Singh Mini P.2

Affiliation:

1. Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

2. Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Abstract

Background: Initial reports of immunotherapy using intralesional Mycobacterium w (Mw) vaccine have documented its useful role in treatment of genital and extragenital warts. Objectives: To compare the efficacy and safety of intralesional Mw vaccine versus cryotherapy in the treatment of refractory extragenital warts. Methods: This was a prospective, randomized, comparative study of 66 patients. The outcome was assessed in terms of complete clearance of warts and change in Dermatology Life Quality Index (DLQI) score. Results: Complete clearance of treated warts was seen in 66.7% (20/30) and 65.5% (19/29) of patients in the Mw and cryotherapy groups, respectively ( P = .769). Clearance of distant warts was significantly ( P = .004) high in the Mw group. Improvement in DLQI was greater in the Mw group. Both treatment modalities were well tolerated, and no major side effects occurred. Conclusions: Mw vaccine and cryotherapy are equally efficacious in treatment of refractory extragenital warts. Mw vaccine has an added advantage of clearance of distant warts.

Publisher

SAGE Publications

Subject

Dermatology,Surgery

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