The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation-Reference-Cited by-同舟云学术

The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation

Published:2008-06 Issue:2 Volume:13 Page:120-129
ISSN:1074-2484
Container-title:Journal of Cardiovascular Pharmacology and Therapeutics
language:en
Short-container-title:J Cardiovasc Pharmacol Ther

Author:

Mollace Vincenzo¹,Ragusa Salvatore²,Sacco Iolanda²,Muscoli Carolina³,Sculco Francesca²,Visalli Valeria²,Palma Ernesto²,Muscoli Saverio⁴,Mondello Luigi⁵,Dugo Paola⁵,Rotiroti Domenicantonio²,Romeo Francesco⁴

Affiliation:

1. University “Magna Graecia" of Catanzaro, Italy, , San Raffaele Pisana IRCCS, Rome, Italy, Centro di Ricerca Salus, Bruzzano Zeffirio (Rc), Italy, Institute Mondino-Tor Vergata, Rome, Italy

2. University “Magna Graecia" of Catanzaro, Italy

3. University “Magna Graecia" of Catanzaro, Italy, San Raffaele Pisana IRCCS, Rome, Italy, Institute Mondino-Tor Vergata, Rome, Italy

4. University of Rome “Tor Vergata", Rome, Italy

5. University of Messina, Italy

Abstract

Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1 expression and free radical generation in a model of rat angioplasty. Common carotid arteries injured by balloon angioplasty were removed after 14 days for histopathological, biochemical, and immunohistochemical studies. Balloon injury led to a significant restenosis with SMC proliferation and neointima formation, accompanied by increased expression of LOX-1 receptor, malondialdehyde and superoxide formation, and nitrotyrosine staining. Pretreatment of rats with BEO-NVF reduced the neointima proliferation together with free radical formation and LOX-1 expression in a dose-dependent manner. These results suggest that natural antioxidants may be relevant in the treatment of vascular disorders in which proliferation of SMCs and oxyLDL-related endothelial cell dysfunction are involved.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1074248407313821

Reference39 articles.

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2. Smooth Muscle Cell Proliferation Is Proportional to the Degree of Balloon Injury in a Rat Model of Angioplasty

3. Patterns and Mechanisms of In-Stent Restenosis

4. Intracoronary stenting for acute and threatened closure complicating percutaneous transluminal coronary angioplasty.

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