Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Induced by Amiodarone: A Report on Two Cases-Reference-Cited by-同舟云学术

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Induced by Amiodarone: A Report on Two Cases

Published:2002-03 Issue:1 Volume:7 Page:25-28
ISSN:1074-2484
Container-title:Journal of Cardiovascular Pharmacology and Therapeutics
language:en
Short-container-title:J Cardiovasc Pharmacol Ther

Author:

Ikegami Haruhiko¹,Shiga Tsuyoshi²,Tsushima Toshio³,Nirei Takashi⁴,Kasanuki Hiroshi⁵

Affiliation:

1. Department of Cardiology, The Heart Institute of Japan; Department of Internal Medicine, Ebara Metropolitan Hospital, Tokyo, Japan

2. Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo 162-8666, Japan

3. Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, Japan

4. Department of Internal Medicine, Ebara Metropolitan Hospital, Tokyo, Japan

5. Department of Cardiology, The Heart Institute of Japan

Abstract

Background: Amiodarone is an effective antiarrhythmic agent for life-threatening arrhythmias but has some noncardiac toxicity. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by amiodarone during long-term therapy seems to be rare among adverse effects. Subjects and Results: We report on two elderly cases that developed hyponatremia caused by SIADH occurring during the initial loading period of amiodarone therapy. Both cases improved within 3 weeks after reduction of the dose, although amiodarone was continued. Conclusions: Amiodarone-induced SIADH may occur during the initial loading period, and it may be improved by reduction of the dose without discontinuation of the drug.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/107424840200700i104

Reference10 articles.

1. Amiodarone: Reevaluation of an Old Drug

2. Hyponatremia During Therapy With Amiodarone

3. Drug-induced syndrome of inappropriate antidiuretic hormone secretion

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