Atherosclerosis in Type 2 Diabetes Mellitus: The Role of Insulin Resistance-Reference-Cited by-同舟云学术

Atherosclerosis in Type 2 Diabetes Mellitus: The Role of Insulin Resistance

Published:2003-12 Issue:4 Volume:8 Page:253-260
ISSN:1074-2484
Container-title:Journal of Cardiovascular Pharmacology and Therapeutics
language:en
Short-container-title:J Cardiovasc Pharmacol Ther

Author:

Watson Karol E.¹,Peters Harmel Anne L.²,Matson Gary

Affiliation:

1. Division of Cardiology, The David Geffen School of Medicine at UCLA, Los Angeles, Calif;

2. University of Southern California Keck School of Medicine, Los Angeles, Calif, and the Institute for Insulin Resistance Studies, Durham, NC

Abstract

Type 2 diabetes mellitus is associated with a marked increase in the risk of atherosclerotic diseases, including coronary heart disease, peripheral arterial disease, and cerebrovascular disease. Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus. Insulin resistance and its attendant metabolic abnormalities may cause much of the increased cardiovascular risk of type 2 diabetes mellitus. Among the abnormalities associated with insulin resistance are dyslipidemia, hypertension, systemic inflammation, and a prothrombotic state. This review discusses the role that each of these disorders plays in the cardiovascular risk of type 2 diabetes mellitus.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/107424840300800402

Reference50 articles.

1. Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study

2. Epidemiology of the insulin resistance syndrome

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