The Emerging Role of Biological Sex in Cell Therapy for Spinal Cord Injury-Reference-Cited by-同舟云学术

The Emerging Role of Biological Sex in Cell Therapy for Spinal Cord Injury

Published:2023-01 Issue: Volume:18 Page:263310552311531
ISSN:2633-1055
Container-title:Neuroscience Insights
language:en
Short-container-title:J Exp Neurosci

Author:

Tucker Ashley¹²,Dulin Jennifer N¹²^ORCID

Affiliation:

1. Department of Biology, Texas A&M University, College Station, TX, USA

2. Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, USA

Abstract

Neural progenitor cell (NPC) transplantation is a promising potential therapy for replacing spinal cord neurons and glial cells following spinal cord injury (SCI). Despite the rapid advancement of NPC transplantation to SCI clinical trials, we still lack understanding of fundamental biology underlying how NPC grafts interact with the injured host nervous system. Our recent study demonstrated a potent effect of biological sex mismatch between donor and host on graft immune rejection. Here we discuss the implications of this study in the context of clinical trials for SCI, and important topics for future research in SCI cell transplantation.

Funder

Wings for Life

Craig H. Neilsen Foundation

National Institute of Neurological Disorders and Stroke

Publisher

SAGE Publications

Subject

General Neuroscience

Link

http://journals.sagepub.com/doi/pdf/10.1177/26331055231153128

Reference22 articles.

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