Affiliation:
1. Portland Alcohol Research Center, Department of Behavioral Neuroscience at Oregon Health and Science University and VA Portland Health Care System, Portland, OR, USA
2. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA
3. Waggoner Center for Alcoholism and Addiction Research, University of Texas at Austin, Austin, TX, USA
Abstract
High Drinking in the Dark (HDID-1) mice represent a unique genetic risk model of binge-like drinking and a novel means of screening potential pharmacotherapies to treat alcohol use disorders (AUDs). We tested the effects of tacrolimus (0, 0.5, 1, and 2 mg/kg), sirolimus (0, 5, 10, and 20 mg/kg), palmitoylethanolamide (PEA; 0, 75, 150, and 225 mg/kg), and secukinumab (0, 5, 20, and 60 mg/kg) on binge-like ethanol intake (2-day, “Drinking in the Dark” [DID]) and blood alcohol levels (BALs) in HDID-1 mice. Tacrolimus reduced ethanol intake and BALs. Tacrolimus had no effect on water intake, but reduced saccharin intake. There was no effect of sirolimus, PEA, or secukinumab on ethanol intake or BALs. These results compare and contrast with previous work addressing these compounds or their targeted mechanisms of action on ethanol drinking, highlighting the importance of screening a wide range of models and genotypes to inform the role of neuroimmune signaling in AUDs.
Funder
National Institute on Alcohol Abuse and Alcoholism
US Department of Veterans Affairs Grants
John R. Andrews Family
Cited by
3 articles.
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