Excretion of Barbiturates into Induced Parotid Saliva of the Rat-Reference-Cited by-同舟云学术

Excretion of Barbiturates into Induced Parotid Saliva of the Rat

Published:1976-01 Issue:1 Volume:55 Page:43-47
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Piraino Anthony J.¹,Digregorio G. John¹,Nagle B.T.¹

Affiliation:

1. Department of Pharmacology, Hahnemann Medical Center, 235 N. 15th Street, Philadelphia, Pennsylvania 19102, USA

Abstract

Anesthetic doses of barbiturates administered to rats were excreted into the parotid saliva. Plasma-saliva concentration ratios were compared to several physicochemical parameters-lipid-water partition coefficient (L/W), degree of ionization, and plasma protein binding-of which L/W appears to correlate best with the excretion of barbiturates into parotid saliva.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345760550012201

Reference15 articles.

1. Salivary Excretion of Sulphonamides and Barbiturates by Cows and Goats

2. Comparison of rat salivas evoked by auriculo-temporal and pilocarpine stimulation

3. The effects of different stimuli on the composition of saliva in man

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