Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications-Reference-Cited by-同舟云学术

Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

Published:2009-04 Issue:4 Volume:88 Page:300-306
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Hennessey P.T.¹²³,Westra W.H.¹²³,Califano J.A.¹²³

Affiliation:

1. Department of Otolaryngology-Head and Neck Surgery and

2. Department of Pathology, Johns Hopkins Medical Institutions, 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287-0910, USA; and

3. Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD 21205, USA

Abstract

Over the past 20 years, high-risk human papilloma-virus (HPV) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. In particular, HPV is strongly associated with the development of oropharyngeal cancer and a small minority of oral cavity cancers. In this review, we summarize what is currently known about the biology of HPV, the mechanisms by which it effects malignant transformation, and the potential impact of HPV status on the clinical management of persons with head and neck cancer.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/0022034509333371

Reference93 articles.

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