Lack of Relationship Between the Degree of Induced Gingival Hyperplasia and the Concentration of Diphenylhydantoin in Various Tissues of Ferrets-Reference-Cited by-同舟云学术

Lack of Relationship Between the Degree of Induced Gingival Hyperplasia and the Concentration of Diphenylhydantoin in Various Tissues of Ferrets

Published:1972-03 Issue:2 Volume:51 Page:657-662
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Steinberg Arnold D.¹,Alvarez Julian¹,Jeffay Henry¹

Affiliation:

1. Department of Periodontics, College of Dentistry, University of Illinois Medical Center, Chicago, Illinois 60612, USA, Department of Biological Chemistry, College of Medicine, University of Illinois Medical Center, Chicago, Illinois 60612, USA

Abstract

Ferrets that were given 5-5 diphenylhydantoin developed various degrees of gingival hyperplasia. Analysis for 5-5 diphenylhydantoin did not show a correlation between the degree of hyperplasia, concentrations of the drug in the various tissues, or turnover of protein-3H proline. Highest concentratrations of the drug were found in oral mucosa, salivary glands, and adrenal glands, and gingiva concentrations were low.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345720510026801

Reference17 articles.

1. THE TREATMENT OF EPILEPSY WITH SODIUM DIPHENYL HYDANTOINATE

2. Antihistaminic Therapy for Gingival Hyperplasia Due to Dilantin

3. Effect of Dilantin Sodium on Tensile Strength of Healing Wounds.

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1. Diseases of the Gastrointestinal System;Biology and Diseases of the Ferret;2014-03-28

2. Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth;Journal of Periodontal Research;1999-04

3. Oral microflora of the ferret at the gingival sulcus and mucosa membrane in relation to ligature-induced periodontitis;Oral Microbiology and Immunology;1994-02

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