Virulence of Streptococcus mutans: An Antibiotic-Suppressed Rat Model for Studies of Pathogenesis-Reference-Cited by-同舟云学术

Virulence of Streptococcus mutans: An Antibiotic-Suppressed Rat Model for Studies of Pathogenesis

Published:1977-03 Issue:3 Volume:56 Page:205-211
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Michalek Suzanne M.¹,McGhee Jerry R.¹

Affiliation:

1. The Department of Microbiology and The Institute of Dental Research, The University of Alabama in Birmingham, Birmingham, Alabama 35294, USA

Abstract

A simple and effective method of antibiotic suppression of the total indigenous microbial flora of rat dams and their offspring has been developed. This method allowed more effective challenge and subsequent colonization of wean-ling rat pups with a test Streptococcus mutans, since S mutans 6715 was isolated from 95% of the treated rats and only 50% of the non-treated offspring following challenge with a single inoculum of this test microorganism.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345770560030301

Reference28 articles.

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4. Fitzgerald, R.J. , and Jordan, H.V.: Polysaccharide Producing Bacteria and Caries . In: Harris, R.S., ed. Art and Science of Dental Caries Research, Academic Press, Inc., New York, p 79-86, 1968.

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