Stimulation of Bone Formation and Bone Resorption by Fluoride in Thyroparathyroidectomized Rats

Author:

Liu Chung-Ching1,Baylink David J.1

Affiliation:

1. Department of Medicine, University of Washington and Veterans Administration Hospital, Seattle, Washington 98195, USA

Abstract

In TPTX as well as sham-operated rats, F increased periosteal bone formation, decreased endosteal bone formation and endosteal osteoid maturation rate, and increased endosteal bone resorption. Serum iPTH was not affected by F treatment. Thus, the effects of F on bone are not mediated by PTH.

Publisher

SAGE Publications

Subject

General Dentistry

Reference25 articles.

1. Baylink, D.; Wergedal, J.; Stauffer, M.; and Rich, C. "Effect of Fluoride on Bone Formation, Mineralization, and Resorption in the Rat," in Vischer, T.L. (ed) : Fluoride in Medicine, Bern: Hans Huber Publishers, 1970, p. 192.

2. Nichols, G., JR. ; Flanagan, B.; and Woods, J.F. "Parathyroid Influences on Bone Biosynthetic Mechanisms," in Gaillard, P.J.; Talmage, R.V.; and Budy, A.M. (ed): The Parathyroid Glands: Ultrastructure, Secretion and Function, Chicago: University of Chicago Press, 1965, p 353.

3. Effect of Sodium Fluoride on the Ultra-structure of the Parathyroid Glands of the Sheep

4. Inhibition of Bone Resorption in the Rabbit by Fluoride

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