Antiproliferative Effects of 9-P-D-Arabinofuranosyladenine in a Mammalian Cell Line Devoid of Adenosine Deaminase Activity-Reference-Cited by-同舟云学术

Antiproliferative Effects of 9-P-D-Arabinofuranosyladenine in a Mammalian Cell Line Devoid of Adenosine Deaminase Activity

Published:1977-03 Issue:3 Volume:56 Page:275-288
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Drach John C.¹,Sandberg Jean N.¹,Shipman Charles¹

Affiliation:

1. The Dental Research Institute, Department of Oral Biology, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109, USA

Abstract

The antiviral drug arabinosyladenine inhibited cellular growth and DNA synthesis in an adenosine deaminase-negative cell line (B-mix K-44/6). Use of adenosine deaminase-containing calf serum in the culture medium reversed the drug-induced inhibition and resulted in a recovery of both mitosis and the rate of DNA synthesis.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345770560031301

Reference48 articles.

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4. The Antiviral Activity of 9-β-D-Arabinofuranosyladenine (ARA-A)

5. Shannon, W.M.: Adenine Arabinoside: Antiviral Activity In Vitro, in Pavan-Langston, D.; Buchanan, R.A.; and Alford, C.A., Jr. (eds) : Adenine Arabinoside : An Antiviral Agent, New York: Raven Press, 1975, pp 1-43.

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