Thymocyte Activating Factor(s) in Human Gingival Fluids

Author:

Mergenhagen S.E.1

Affiliation:

1. Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205

Abstract

Human gingival fluid contains a low-molecular-weight factor (10,000 to 25,000) which enhances the proliferation of murine thymocytes in the presence of suboptimal doses of mitogen. Although the gingival fluid has no Interleukin 2 (T cell growth factor) activity, as indicated by its inability to induce proliferation of an IL 2 dependent lymphocytic cell line, it is directly mitogenic for dermal fibroblasts. These studies suggest that the thymocyte and fibroblast growth-promoting properties of human gingival fluid may have important functions in regulating inflammatory responses in the human periodontal tissues.

Publisher

SAGE Publications

Subject

General Dentistry

Reference24 articles.

1. Lehner, T.: Cellular Immunity in Periodontal Disease: An Overview. In: Host-Parasite Interactions in Periodontal Diseases, Genco, R.J. and Mergenhagen, S.E., Eds. Washington, D.C. American Society for Microbiology, 1982, pp. 202-216.

2. Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes

3. Sandberg, A.L. : Humoral and Cellular Mediation of Bone Resorption . In: Host-Parasite Interactions in Periodontal Diseases, Genco, R.J. and Mergenhagen, S.E., Eds. Washington, D.C.: American Society for Microbiology, 1982, pp. 309-317.

4. Wahl, S.M.: Mononuclear Cell-Mediated Alterations in Connective Tissue. In: Host-Parasite Interactions in Periodontal Diseases, Genco, R.J. and Mergenhagen, S.E., Eds. Washington, D.C.: American Society for Microbiology, 1982, pp. 225-234.

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