Affiliation:
1. Faculty of Dentistry, University of Toronto, 124 Edward St., Toronto, Ontario, Canada M5G 1G6
Abstract
Two antimicrobial varnishes were developed to be applied to the teeth for the eradication of Streptococcus mutans infections. One of them contained chlorhexidine acetate as the antimicrobial agent and the other, erythromycin base. Both varnishes contained Sumatra benzoin. Each of the two antimicrobial agents was shown to be highly effective against S. mutans and to be compatible with the benzoin vehicle. When applied to extracted teeth, both varnishes dried to form a tough, adherent, and colorless transparent layer. Dried samples of the varnishes, when suspended in frequently-changed buffer, released their microbial agents at low but bactericidal levels for at least 12 days. After the first day, drug release from the chlorhexidine varnish showed approximately zero-order kinetics, while the erythromycin varnish showed a combination of zero-order and first-order kinetics.
Reference36 articles.
1. Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline
2. Antimicrobial Susceptibility of
Streptococcus mutans
Isolated from Patients with Endocarditis
3. Barry, A.L. (1981): Microbiological Methods for Monitoring Antibiotics in Body Fluids. In: Interpretations in Therapeutic Drug Monitoring , D.M. Baer and W.R. Dito, Eds. Chicago, IL: American Society of Clinical Pathologists, pp. 205-219.
4. Barry, A.L. and Sabath, L.D. (1974): Special Tests: Bactericidal Activity and Activity of Antimicrobics in Combination. In: Manual of Clinical Microbiology , 2nd ed. E.H. Lennette, E.H. Spaulding, and J.P. Truant, Eds. Washington, D.C . American Society for Microbiology, pp. 431-435.
5. The early establishment of Streptococcus mutans in the mouths of infants
Cited by
59 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献