Effects of MMP Inhibitors Incorporated within Dental Adhesives

Author:

Almahdy A.12,Koller G.1,Sauro S.1,Bartsch J.W.13,Sherriff M.1,Watson T.F.14,Banerjee A.4

Affiliation:

1. Biomaterials, Biomimetics & Biophotonics Research Group, King’s College London Dental Institute at Guy’s Hospital, King’s Health Partners, London, UK

2. Dental Caries Research Chair, Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Saudi Arabia

3. Department of Neurosurgery, Philipps-University Marburg, UKGM Marburg, Baldingerstr., Marburg, Germany

4. Unit of Conservative Dentistry, King’s College London Dental Institute at Guy’s Hospital, King’s Health Partners, Floor 26, Tower Wing, Guy's Dental Hospital London Bridge, London SE1 9RT, UK

Abstract

Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when applied as a pre-conditioner, adding to clinical steps in the placement of adhesives, but their incorporation within dental adhesives has not been fully explored. This study examined the effect of including 2 MMP inhibitors (BB94 and GM6001) within the primers of 3 commercially available adhesives. Fluorometric assay and zymography showed that adhesives with MMP inhibitors had high affinity toward both synthetic fluorogenic FRET peptides (95%) and dentin powder substrates, respectively. The immediate microtensile bond strength was enhanced for 2 types of adhesives following the addition of both inhibitors. However, no changes were detected between the control and the inhibitor groups following 3-month storage. The modified two-step etch-and-rinse and single-step systems showed less Rhodamine B penetration to the “hybrid layer” and to the “adhesive”, respectively. The incorporation of BB94 and GM6001 within the primers resulted in the inhibition of dentin MMPs with improved initial bond strength and enhanced sealing ability.

Publisher

SAGE Publications

Subject

General Dentistry

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