In vitro Testing of Plaque Control Agents-Reference-Cited by-同舟云学术

In vitro Testing of Plaque Control Agents

Published:1979-12 Issue:12 Volume:58 Page:2396-2403
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Coburn Robert A.¹

Affiliation:

1. Department of Medicinal Chemistry, State University of New York at Buffalo, School of Pharmacy, Buffalo, New York

Abstract

The development of a number of in vitro techniques for the evaluation of antiplaque effects of test agents has followed the characterization and culturing of plaque-forming microorganisms. Studies of the mechanism of action of chlorhexidine and clinical observations have assisted in defining critical aspects of these in vitro techniques. Such assays may play an increasingly important role in screening potential new agents as well as in the optimization of properties by chemical modification of new lead agents. In addition, data generated in the in vitro assay may assist the design of in vivo evaluations of new agents. Proper selection of in vitro techniques for these various functions in the preclinical development process may reduce the time and cost involved in the development of new antiplaque agents.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345790580120904

Reference27 articles.

1. Jennings, J.: Government Regulation and Drug Development: FDA. In: Drug Discovery , B. Bloom and G. E. Ullyot, eds. Advances in Chemistry Series, 108, Washington, D.C.: American Chemical Society, 1971, Chapter 13, pp. 247-256.

2. The Rate of Contemporary Drug Discovery

3. Overberger, C.G. : Chairman of Committee on Chemistry and Public Affairs: "Chemistry and Medicine," Washington, D. C., American Chemical Society, 1977, p. 27.

4. Development of an in-vitro plaque model from human salivary sediment suspensions

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mittel zur Körperpflege und Hygiene;Waren und Dienste;1990

2. The effect of Octapinol on dento-gingival plaque and development of gingivitis.;Journal of Periodontal Research;1983-08

3. Activity of Sodium Ricinoleate Against In Vitro Plaque;Journal of Pharmaceutical Sciences;1982-12