The Novel Gene Locus for Agenesis of Permanent Teeth (He-Zhao deficiency) Maps to Chromosome 10q11.2-Reference-Cited by-同舟云学术

The Novel Gene Locus for Agenesis of Permanent Teeth (He-Zhao deficiency) Maps to Chromosome 10q11.2

Published:2001-08 Issue:8 Volume:80 Page:1716-1720
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Liu W.¹,Wang H.²,Zhao S.³,Zhao W.⁴,Bai S.²,Zhao Y.⁵,Xu S.⁵,Wu C.⁵,Huang W.⁵,Chen Z.⁵,Feng G.²,He L.⁶

Affiliation:

1. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, P.R. China, Bio-X Life Science Research Center, PO Box 501, Hao Ran Building, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China

2. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, P.R. China

3. Junior Middle School of Xunyi County, Shanan Xi province, P.R. China

4. Hospital of Xunyi County, Shanan Xi province, P.R. China

5. Chinese National Human Genome Center at Shanghai, Shanghai, P.R. China

6. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, P.R. China, , Bio-X Life Science Research Center, PO Box 501, Hao Ran Building, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China

Abstract

He-Zhao deficiency has been recently characterized with a distinct form of agenesis of permanent teeth that is different from other previously reported disorders of tooth agenesis. This inherited abnormality suggests that some gene(s) associated with the development of permanent teeth may mutate. In this study, we map the gene locus to chromosome 10q11.2. The DNA pooling method combined with two-point and multi-point linkage analysis has been successfully applied. The maximum LOD (Zmax) scores for two-point and multi-point analyses are 13.29 (on marker D10S196) at recombination fraction (θ) = 0 and 18.09 (between markers D10S1772 and D10S1766), respectively. Haplotype analysis confined the locus within an interval of 5.5 cM flanked by markers D10S604 and D10S568. This study has demonstrated a novel gene locus responsible for He-Zhao deficiency and provides a good likelihood for the discovery of one of the genes determining permanent tooth formation and development.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345010800080701

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