Surface-Chemical Studies on Chlorhexidine and Related Compounds: II. Interactions with Monomolecular-Film Systems

Author:

Fisher Richard G.1,Quintana Ronald P.1

Affiliation:

1. Surface Chemistry Laboratory, Department of Medicinal Chemistry, College of Pharmacy, University of Tennessee Medical Units, Memphis, Tennessee 38163, USA

Abstract

Interactions of chlorhexidine and structurally related biguanides with selected monomolecular-film systems (that is, stearic acid, stearyl alcohol, and N-octadecylacetamide) were explored. The data reflected the significance of ionic associations between the compounds and stearic acid films and, in the instance of the biguanide analogs, indicated that the length of the alkyl chain was an important factor in the penetration process.

Publisher

SAGE Publications

Subject

General Dentistry

Reference18 articles.

1. Surface-Chemical Studies on Chlorhexidine and Related Compounds: 1. Effects at Air-Water, n-Hexane-Water, and Hydroxyapatite-Water Interfaces

2. Quintana, R.P.; Lasslo, A.; Clark, J.W.; and Baier, R.E.: Surface-Chemical Approach to the Prevention of Pathological Accumulations of Dental Deposits, in Lasslo, A., and Quintana, R.P. (eds) : Surface Chemistry and Dental Integuments, Springfield, Ill.: Charles C Thomas, 1973, pp 392-413.

3. Quintana, R.P.; Lasslo, A.; and Fisher, R.G.: Surface Chemistry in the Study of Biological Systems, in Lasslo, A., and Quintana, R.P. (eds) : Surface Chemistry and Dental Integuments, Springfield, Ill.: Charles C Thomas, 1973, pp 276-336.

4. Relationships between Surface Activity and Biological Activity of Drugs

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