Clinical Science

Author:

Elattar Tawfik M.A.1,Lin Hsien S.1

Affiliation:

1. Laboratory of Hormone Research, University of Missouri, School of Dentistry, Kansas City, Missouri 64108

Abstract

The levels of cAMP were measured by means of radioimmunoassay in 20 gingival samples free from inflammatory cells and 43 samples with moderately dense and dense aggregations of inflammatory cells. The average values were found to be 340 ± 44 and 552 ± 59 pmol/gm wet tissue, respectively. The increase in cAMP levels in inflammation is suggested to be modulated by an increase in endogenous prostaglandin synthesis and could be one of the natural mechanisms by which the host protects itself from dangerous consequences of unregulated immune response.

Publisher

SAGE Publications

Subject

General Dentistry

Reference15 articles.

1. Higgs, G.A.; Vane, J.T.; Hart, F.D.; and Wajtuleski, J.A. : Effects of Anti-inflammatory Drugs on Prostaglandins in Rheumatoid Arthritis. In: Prostaglandin Synthetase Inhibitors , H. J. Robinson and J. R. Vane, Eds. New York: Raven Press, 1974, pp. 165-174.

2. Robinson, D.R. and Levine, L.: Prostaglandin Concentrations in Synovial Fluid in Rheumatic Diseases: Action of Indomethacin and Aspirin. In: Prostaglandin Synthetase Inhibitors , H. J. Robinson and J. R. Vane, Eds. New York: Raven Press, 1974, pp. 223-228.

3. PROSTAGLANDINS IN THE RHEUMATIC DISEASES

4. Cyclic 3′,5′-adenosine monophosphate in the human leukocyte: synthesis, degradation, and effects on neutrophil candidacidal activity

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