Mechanisms of Viral Infections Associated with HIV

Author:

Tugizov S.M.1,Webster-Cyriaque J.Y.2,Syrianen S.3,Chattopadyay A.4,Sroussi H.5,Zhang L.6,Kaushal A.7

Affiliation:

1. Department of Medicine, School of Medicine, University of California, San Francisco, USA

2. School of Dentistry, University of North Carolina at Chapel Hill, North Carolina, USA

3. Institute of Dentistry and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland

4. National Institutes of Health, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA

5. University of Illinois at Chicago, College of Dentistry, Chicago, Illinois, USA

6. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

7. National Center for Safety Pharmacology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India

Abstract

HIV infection is commonly associated with activation and dissemination of several other viral pathogens, including herpes simplex virus 1/2, human cytomegalovirus, human herpesvirus 8, Epstein-Barr virus, Varicella Zoster virus, and human papillomavirus, which behave as opportunistic agents and cause various diseases in immunocompromised hosts. The increased frequency and severity of diseases caused by these viruses in HIV-infected individuals is due mainly to dysfunction of both the adaptive and innate immune responses to viral pathogens. In addition, molecular interactions between HIV and these opportunistic viruses are likely to play critical roles in the progression of disease, including neoplasia. This report reviews the critical aspects of HIV interaction with opportunistic viruses, including Epstein-Barr virus, human cytomegalovirus, herpes simplex virus, Varicella Zoster virus, human herpesvirus 8, and human papillomavirus.

Publisher

SAGE Publications

Subject

General Medicine

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