Enhanced Collagenase Activity in Diabetic Rat Gingiva: In Vitro and In Vivo Evidence-Reference-Cited by-同舟云学术

Enhanced Collagenase Activity in Diabetic Rat Gingiva: In Vitro and In Vivo Evidence

Published:1978-03 Issue:3 Volume:57 Page:520-525
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Golub Lorne M.¹,Schneir Michael²,Ramamurthy N.S.¹

Affiliation:

1. Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York, Stony Brook, NY 11794, USA

2. Department of Biochemistry, School of Dentistry, University of Southern California, Los Angeles, California 90007, USA

Abstract

Gingiva from alloxan and streptozotocin-diabetic rats exhibited markedly enhanced collagenolytic activity in tissue culture. This effect was eliminated by puromycin or by repeated freeze-thawing of the tissue prior to incubation. Soluble extracts of the diabetic gingiva in situ were found to contain breakdown products of collagen similar in size to the reaction products generated by tissue collagenase. These fragments were not detected in the control tissue. This study indicates that experimental diabetes stimulates the synthesis of gingival collagenase in culture and that a similar effect occurs in vivo.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/00220345780570032101

Reference44 articles.

1. Influence of Diabetes Mellitus on the Severity of Periodontal Disease

2. Diabetes Mellitus and Periodontal Disease

3. The Relationship Between Periodontal State and Diabetes Duration, Insulin Dosage and Retinal Changes

4. Postsurgical Periodontal Healing in Alloxan Diabetes

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