Chromosomal Numerical Aberrations in Oral Lichen Planus-Reference-Cited by-同舟云学术

Chromosomal Numerical Aberrations in Oral Lichen Planus

Published:2009-05 Issue:5 Volume:88 Page:427-432
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Yarom N.¹²³⁴,Shani T.¹²³⁴,Amariglio N.¹²³⁴,Taicher S.¹²³⁴,Kaplan I.¹²³⁴,Vered M.¹²³⁴,Rechavi G.¹²³⁴,Trakhtenbrot L.¹²³⁴,Hirshberg A.¹²³⁴

Affiliation:

1. Department of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel;

2. Cancer Research Center, The Chaim Sheba Medical Center, Tel-Hashomer, Israel;

3. Institute of Pathology, Rabin Medical Centre, Beilinson Campus, Petah-Tiqva, Israel; and

4. Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel

Abstract

The malignant potential of oral lichen planus (OLP) has been a matter of serious controversy. We aimed to detect chromosomal numerical aberrations in cells of brush samples collected from affected mucosa. The samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) with chromosomes 2 and 8 centromeric probes. We analyzed 57 persons with OLP and 33 control individuals. A cut-off value of aneuploid cells was determined as 1.1%. Aneuploid cells were found in 16 persons with OLP (28.1%); in 10 individuals (17.5%), over 5% of the cells were aneuploid. Aneuploid cells were also detected in normal-looking mucosa of seven persons with OLP. One person with OLP developed squamous cell carcinoma; 10% of the cells examined were aneuploid. OLP carries an increased risk for chromosomal instability. Identifying aneuploid cells in a brush sample and the combined morphological and FISH analysis can increase the specificity in predicting the malignant potential of OLP.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/0022034509337089

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