Remineralization of Enamel Subsurface Lesions by Sugar-free Chewing Gum Containing Casein Phosphopeptide-Amorphous Calcium Phosphate

Author:

Shen P.1,Cai F.1,Nowicki A.1,Vincent J.2,Reynolds E.C.3

Affiliation:

1. School of Dental Science, The University of Melbourne, 711 Elizabeth Street, Melbourne, Victoria, 3000 Australia

2. Warner Lambert Consumer Group, Pfizer Inc., Morris Plains, NJ, USA

3. School of Dental Science, The University of Melbourne, 711 Elizabeth Street, Melbourne, Victoria, 3000 Australia,

Abstract

Casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) exhibit anticariogenic potential in laboratory, animal, and human in situ experiments. The aim of this study was to determine the ability of CPP-ACP in sugar-free chewing gum to remineralize enamel subsurface lesions in a human in situ model. Thirty subjects in randomized, cross-over, double-blind studies wore removable palatal appliances with six human-enamel half-slabs inset containing subsurface demineralized lesions. The appliances were inserted immediately before gum-chewing for 20 min and then retained for another 20 min. This was performed four times per day for 14 days. At the completion of each treatment, the enamel half-slabs were paired with their respective demineralized control half-slabs, embedded, sectioned, and subjected to microradiography and densitometric image analysis, for measurement of the level of remineralization. The addition of CPP-ACP to either sorbitol- or xylitol-based gum resulted in a dose-related increase in enamel remineralization, with 0.19, 10.0, 18.8, and 56.4 mg of CPP-ACP producing an increase in enamel remineralization of 9, 63, 102, and 152%, respectively, relative to the control gum, independent of gum weight or type.

Publisher

SAGE Publications

Subject

General Dentistry

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