Butyrate Inhibits Dendritic Cell Activation and Alleviates Periodontitis

Author:

Wu L.12,Luo Z.12,Chen Y.12,Yan Z.12,Fu J.12,Jiang Y.12,Xu J.12,Liu Y.12

Affiliation:

1. Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, P. R. China

2. Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China

Abstract

Dendritic cells (DCs) can mediate inflammation-related bone resorption that is crucial in the development of periodontitis. Butyrate is a critical by-product of microbes with antibacterial and anti-inflammatory properties. Here, we found that butyrate inhibited the activation of lipopolysaccharide (LPS)–induced DCs and generation of inflammatory cytokines by DCs. Moreover, butyrate regulated glycolysis in LPS-induced DCs via the G-protein-coupled receptor/hypoxia-inducible factor–1α pathway. In addition, butyrate inhibited the maturation of CD11c+MHC-II+ DCs in vivo, suppressing local inflammatory infiltration and ultimately alleviating bone resorption in a periodontitis model. Our results imply that butyrate suppresses the activation of LPS-induced DCs by modulating their metabolism, highlighting its potential as a therapeutic agent for inflammatory diseases.

Funder

national key research and development program of china

national natural science foundation of china

Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support

Innovation Research Team Project of Beijing Stomatological Hospital, Capital Medical University

Publisher

SAGE Publications

Subject

General Dentistry

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