Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later

Author:

González Michael J.1,Miranda-Massari Jorge R.2,Mora Edna M.3,Guzmán Angelik4,Riordan Neil H.5,Riordan Hugh D.,Casciari Joseph J.,Jackson James A.6,Román-Franco Angel7

Affiliation:

1. University of Puerto Rico, Medical Sciences Campus, Graduate School of Public Health, Department Human Development, Nutrition Program, PO Box 365067, San Juan, PR 00936-5067 .

2. School of Pharmacy, Department of Pharmacy Practice, University of Puerto Rico, San Juan.

3. School of Medicine, Surgery Division, University of Puerto Rico, and Puerto Rico Cancer Center, San Juan, Puerto Rico.

4. RECNAC II Project, University of Puerto Rico, Medical Sciences Campus, School of Public Health, Department of Human Development, Nutrition Program, San Juan, Puerto Rico.

5. Ai Dan Incorp, Tempe, Arizona.

6. Center for the Improvement of Human Functioning, Wichita, Kansas.

7. Department of Pathology, University of Puerto Rico, San Juan.

Abstract

The effect of ascorbic acid on cancer has been a subject of great controversy. This is a follow-up review of the 1979 article by Cameron, Pauling, and Leibovitz published in Cancer Research. In this updated version, the authors address general aspects of ascorbic acid and cancer that have been presented before, while reviewing, analyzing, and updating new existing literature on the subject. In addition, they present and discuss their own mechanistic hypothesis on the effect of ascorbic acid on the cancer cell. The objective of this review is to provide an updated scientific basis for the use of ascorbic acid, especially intravenously as adjuvant treatment in pharmacological nutritional oncology.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Oncology

Reference173 articles.

1. New Concepts in the Biology and Biochemistry of Ascorbic Acid

2. Guthrie H. Introductory Nutrition. 7th ed. St. Louis, Mo: Mosby College Publishing; 1989:381-382.

3. Antioxidant Functions of Vitamins

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