Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review

Author:

Ooi Soo Liang1ORCID,Campbell Ron12,Pak Sok Cheon1,Golombick Terry3,Manoharan Arumugam45,Ramakrishna Raj45,Badmaev Vladimir6ORCID,Schloss Janet7

Affiliation:

1. Charles Sturt University, Bathurst, NSW, Australia

2. The Oaks Medical Practice, The Oaks, NSW, Australia

3. St George Hospital, Kogarah, NSW, Australia

4. Southern Sydney Haematology, Kogarah, NSW, Australia

5. University of Wollongong Australia, Wollongong NSW, Australia

6. American Medical Holdings, Inc., Staten Island, NY, USA

7. Southern Cross University, Lismore, NSW, Australia

Abstract

Myelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating condition, and management options in patients with MDS aim to improve cytopenias, delay disease progression, and enhance quality of life. High serum ferritin levels, a source of iron for reactive oxygen species production, correlate with a higher risk of progression to acute myeloid leukemia, and iron overload is compounded by blood transfusions given to improve anemia. 6-shogaol is a natural phenolic compound formed when ginger is exposed to heat and/or acidic conditions, and it has been shown to possess anti-tumor activity against leukemia cell lines and antioxidant effects. This narrative review assessed the potential benefits of this phytochemical in lower-risk MDS patients through examining the current evidence on the pharmacological and therapeutic properties of ginger and 6-shogaol.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Oncology

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