Anticancer Effects of HESA-A in Patients With Metastatic Colon Cancer-Reference-Cited by-同舟云学术

Anticancer Effects of HESA-A in Patients With Metastatic Colon Cancer

Published:2009-01-15 Issue:1 Volume:8 Page:71-74
ISSN:1534-7354
Container-title:Integrative Cancer Therapies
language:en
Short-container-title:Integr Cancer Ther

Author:

Ahmadi Amrollah¹,Mohagheghi Mohammadali²,Karimi Mehrdad³,Seyed Ali Golestanha ³,Naseri Mohsen³

Affiliation:

1. Institute of Cancer Research, Medical Sciences/University of Tehran, Tehran, Iran,

2. Institute of Cancer Research, Medical Sciences/University of Tehran, Tehran, Iran

3. Shahed University of Medical Sciences Tehran, Iran

Abstract

Background: HESA-A is a natural biological compound of herbal—marine origin. The aim of this study was to investigate the therapeutic effects of HESA-A in patients with metastatic colon cancer. Methods: Fifty consecutive patients with end-stage colon cancer and liver metastasis at the Cancer Research Center of Tehran University of Medical Sciences were studied. Patients received HESA-A 50 mg/kg/d orally in 2 to 3 divided doses for 6 months. The patients were assessed at the start and end of the 1st, 2nd, 4th, 8th, 12th, 16th, 20th, and 26th weeks of the study. The Karnofsky Performance Scale questionnaire was completed for each patient. Results: The mean Karnofsky performance score increased from 33.6 ± 9.8 to 63.3 ± 11 after 10 weeks of study. No significant hepatic or hematological adverse effects were seen during the study. Conclusion: It seems that HESA-A is an effective and safe anticancer drug, which can be used in selected patients.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Oncology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1534735408327995

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