Early Effect of Exogenous Na Hyaluronate on Mucociliary Clearance

Abstract

Background An animal study is performed to determine the early effect of 1% Na hyaluronate on mucociliary clearance function. Methods One percent of Na hyaluronate was introduced into the maxillary sinuses of rabbits by anterior antrostomy. A physiological solution of 1% NaCl was introduced into the maxillary sinuses of a control group to equalize the influence of Na for both groups. The treatment material was sprayed with an atomizer for coating the maxillary sinus lining. Technetium-99m diethylenetriamine pentaacetate dynamic scintigraphic imaging was performed to evaluate mucociliary clearance function on all rabbits 72 hours after the surgical procedure. Results Although the mean rate of mucociliary clearance of the Na hyaluronate group was slightly worse than the control group; there was no statistically significant difference between them. Conclusion There is no early effect of exogenous 1% Na hyaluronate on mucociliary clearance function.