A Model of Allergic Nasal Congestion in Dogs Sensitized to Ragweed

Author:

Rudolph Karin1,Bice David E.1,Hey John A.2,Mcleod Robbie L.2

Affiliation:

1. Respiratory Immunology Program, Lovelace Respiratory Research Institute Albuquerque, New Mexico

2. Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey

Abstract

Background Acoustic rhinometry is a noninvasive method that uses sound waves to measure dimensions of the nasal cavity. Methods In this study, nasal patency was measured by acoustic rhinometry in allergic Beagle dogs sensitized to ragweed allergen. Ragweed (0.03–0.3%) or vehicle were administered intranasally in isoflurane-anesthetized dogs. Results The instillation of ragweed caused a dose-related decrease in nasal cavity volume and minimal cross-sectional area (Amin) without adverse systemic effects. Nasal cavity volume and Amin decreased within 30 minutes after instillation of the highest ragweed dose by 35.1 ± 6.0% and 66.4 ± 13.8%, respectively, and persisted for at least 90 minutes. Oral administration of α-adrenergic agonist, d-pseudoephedrine (3 mg/kg), or histamine H1 antagonist chlorpheniramine (10 mg/kg) blocked the ragweed-induced nasal congestion. Conclusion These results suggest that the canine model may be used to study upper-airway diseases such as allergic rhinitis and to evaluate the pharmacologic activity of nasal decongestants.

Publisher

SAGE Publications

Subject

Otorhinolaryngology

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Nasal Discharge;Common Clinical Presentations in Dogs and Cats;2019-07-03

2. VTX‐1463, a novel TLR‐8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs;Immunity, Inflammation and Disease;2015-12-07

3. Pharmacological Evaluation of Selective α2c-Adrenergic Agonists in Experimental Animal Models of Nasal Congestion;Journal of Pharmacology and Experimental Therapeutics;2014-02-03

4. Allergic rhinitis: An update on disease, present treatments and future prospects;International Immunopharmacology;2011-11

5. VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis;Expert Opinion on Investigational Drugs;2011-05-09

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