The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)-Reference-Cited by-同舟云学术

The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS)

Published:2019-05-06 Issue:10 Volume:39 Page:1267-1276
ISSN:0333-1024
Container-title:Cephalalgia
language:en
Short-container-title:Cephalalgia

Author:

Caria Filomena¹,Zedde Marialuisa²,Gamba Massimo³,Bersano Anna⁴,Rasura Maurizia⁵,Adami Alessandro⁶,Piantadosi Carlo⁷,Quartuccio Luca⁸,Azzini Cristiano⁹,Melis Maurizio¹⁰,Luisa Delodovici Maria¹¹,Dallocchio Carlo¹²,Gandolfo Carlo¹³,Cerrato Paolo¹⁴,Motto Cristina¹⁵,Melis Fabio¹⁶,Chiti Alberto¹⁷,Gentile Mauro¹⁸,Bignamini Valeria¹⁹,Morotti Andrea²⁰,Maria Lotti Enrico²¹,Toriello Antonella²²,Costa Paolo²³,Silvestrelli Giorgio²⁴,Zini Andrea²⁵,De Giuli Valeria¹,Poli Loris¹,Paciaroni Maurizio²⁶,Lodigiani Corrado²⁷,Marcheselli Simona²⁸,Sanguigni Sandro²⁹,Del Sette Massimo³⁰,Monaco Serena³¹,Lochner Piergiorgio³²,Zanferrari Carla³³,Anticoli Sabrina³⁴,Padovani Alessandro¹,Pezzini Alessandro¹^ORCID,

Affiliation:

1. Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italy

2. SC Neurologia, Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia, Reggio Emilia, Italy

3. Stroke Unit, Neurologia Vascolare, Spedali Civili di Brescia, Brescia, Italy

4. UO Malattie Cerebrovascolari, Fondazione IRCCS Istituto Neurologico “Carlo Besta”, Milan, Italy

5. Stroke Unit, Azienda Ospedaliera Sant’Andrea, Università “La Sapienza”, Rome, Italy

6. Stroke Center, Dipartimento di Neurologia, Ospedale Sacro Cuore Negrar, Verona, Italy

7. UOC Neurologia, Azienda Ospedaliera “San Giovanni-Addolorata”, Rome, Italy

8. Clinica di Reumatologia, Dipartimento di Area Medica, Azienda Ospedaliero-Universitaria “Santa Maria della Misericordia”, Udine, Italy

9. UO di Neurologia, Dipartimento di Neuroscienze e Riabilitazione, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy

10. SC Neurologia and Stroke Unit, Dipartimento Neuroscienze e Riabilitazione, Azienda Ospedaliera “G. Brotzu”, Cagliari, Italy

11. Unità di Neurologia, Ospedale di Circolo, Università dell’Insubria, Varese, Italy

12. Dipartimento di Area Medica, UOC Neurologia, ASST Pavia, Voghera, Italy

13. Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università di Genova, Genoa, Italy

14. Dipartimento di Neuroscienze, Stroke Unit, Università di Torino, Torino, Italy

15. Stroke Unit, Dipartmento di Scienze Neurologiche, Azienda Ospedaliera “Niguarda Ca’ Granda”, Milan, Italy

16. SS NeuroVascolare Ospedale Maria Vittoria, ASL Città di Torino, Torino, Italy

17. UO Neurologia, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy

18. UO Neurologia – Stroke Unit, Ospedale “Santa Maria della Misericordia”, Rovigo, Italy

19. Stroke Unit, U.O Neurologia, Ospedale “S. Chiara”, Trento, Italy

20. UC Malattie Cerebrovascolari, IRCCS Fondazione Mondino, Pavia, Italy

21. Unità Operativa Complessa Neurologia, AUSL Romagna, Ravenna, Italy

22. Unità Operativa Complessa Neurologia, Azienda Ospedaliera Universitaria “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy

23. UO Neurologia, Istituto Ospedaliero Poliambulanza, Brescia, Italy

24. Stroke Unit, Dipartimento di Neuroscienze, Ospedale Carlo Poma, Mantova, Italy

25. Stroke Unit, Clinica Neurologica, Nuovo Ospedale Civile “S. Agostino Estense”, AUSL Modena, Italy

26. Stroke Unit and Divisione di Medicina Cardiovascolare, Università di Perugia, Italy

27. Centro Trombosi e Malattie Emorragiche, Humanitas Clinical and Research Center, IRCCS, Rozzano-Milano, Italy

28. Neurologia d’Urgenza and Stroke Unit, Humanitas Clinical and Research Center, IRCCS, Rozzano-Milano, Italy

29. Dipartmento di Neurologia, Ospedale “Madonna del Soccorso”, San Benedetto del Tronto, Italy

30. Unità di Neurologia, E.O. Ospedali Galliera, Genova, Italy

31. Stroke Unit, Ospedale Civico, Palermo, Italy

32. Dipartimento di Neurologia, Saarland University Medical Center, Homburg, Germany

33. UOC Neurologia, ASST Melegnano-Martesana, Vizzolo Predabissi, Italy

34. Stroke Unit, Dipartimento di Emergenza-Urgenza, Ospedale “S. Camillo-Forlanini”, Rome, Italy

Abstract

Introduction To describe clinical, neuroimaging, and laboratory features of a large cohort of Italian patients with reversible cerebral vasoconstriction syndrome. Methods In the setting of the multicenter Italian Project on Stroke at Young Age (IPSYS), we retrospectively enrolled patients with a diagnosis of definite reversible cerebral vasoconstriction syndrome according to the International Classification of Headache Disorders (ICHD)-3 beta criteria (6.7.3 Headache attributed to reversible cerebral vasoconstriction syndrome, imaging-proven). Clinical manifestations, neuroimaging, treatment, and clinical outcomes were evaluated in all patients. Characteristics of reversible cerebral vasoconstriction syndrome without typical causes (“idiopathic reversible cerebral vasoconstriction syndrome”) were compared with those of reversible cerebral vasoconstriction syndrome related to putative causative factors (“secondary reversible cerebral vasoconstriction syndrome”). Results A total of 102 patients (mean age, 47.2 ± 13.9 years; females, 85 [83.3%]) qualified for the analysis. Thunderclap headache at presentation was reported in 69 (67.6%) patients, and it typically recurred in 42 (60.9%). Compared to reversible cerebral vasoconstriction syndrome cases related to putative etiologic conditions (n = 21 [20.6%]), patients with idiopathic reversible cerebral vasoconstriction syndrome (n = 81 [79.4%]) were significantly older (49.2 ± 13.9 vs. 39.5 ± 11.4 years), had more frequently typical thunderclap headache (77.8% vs. 28.6%) and less frequently neurological complications (epileptic seizures, 11.1% vs. 38.1%; cerebral infarction, 6.1% vs. 33.3%), as well as concomitant reversible brain edema (25.9% vs. 47.6%). Conclusions Clinical manifestations and putative etiologies of reversible cerebral vasoconstriction syndrome in our series are slightly different from those observed in previous cohorts. This variability might be partly related to the coexistence of precipitating conditions with a putative etiologic role on disease occurrence.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0333102419849013

Reference15 articles.

1. Narrative Review: Reversible Cerebral Vasoconstriction Syndromes

2. The Typical Thunderclap Headache of Reversible Cerebral Vasoconstriction Syndrome and its Various Triggers

3. Reversible cerebral vasoconstriction syndrome

4. Reversible cerebral vasoconstriction syndrome: an important and common cause of thunderclap and recurrent headaches

5. Clinical Worsening in Reversible Cerebral Vasoconstriction Syndrome

Cited by 27 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Reversibles zerebrales Vasokonstriktionssyndrom;Der Nervenarzt;2024-06

2. Frequency of ischaemic stroke and intracranial haemorrhage in patients with reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES) – A systematic review;European Journal of Neurology;2024-03-12

3. The prevalence of non-contrast CT imaging abnormalities in reversible cerebral vasoconstriction syndrome: A systematic review and meta-analysis;PLOS ONE;2024-03-11

4. Headache Attributed to Reversible Cerebral Vasoconstriction Syndrome (RCVS);Diagnostics;2023-08-22

5. Reversible cerebral Vasoconstriction syndrome intERnational CollaborativE (REVERCE) network: Study protocol and rationale of a multicentre research collaboration;European Stroke Journal;2023-06-17