Are we closer to achieving precision medicine for migraine treatment? A narrative review-Reference-Cited by-同舟云学术

Are we closer to achieving precision medicine for migraine treatment? A narrative review

Published:2024-09 Issue:9 Volume:44 Page:
ISSN:0333-1024
Container-title:Cephalalgia
language:en
Short-container-title:Cephalalgia

Author:

Ihara Keiko¹²,Casillo Francesco³^ORCID,Dahshan Ahmed⁴,Genç Hamit⁵^ORCID,Jusupova Asel⁶,Karbozova Kunduz⁶,Lee Wonwoo⁷^ORCID,Liaw Yi Chia⁸⁹^ORCID,Mavridis Theodoros¹⁰^ORCID,Park Hong-Kyun¹¹^ORCID,Polat Burcu¹²,Unt Triin Helin¹³,Vashchenko Nina¹⁴,Zhantleuova Aisha¹⁵^ORCID,Pozo-Rosich Patricia¹⁶¹⁷^ORCID,Schwedt Todd J.¹⁸^ORCID

Affiliation:

1. Department of Neurology, Keio University School of Medicine, Tokyo, Japan

2. Neurology Department, Japanese Red Cross Ashikaga Hospital, Ashikaga, Japan

3. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy

4. Department of Neurology, Cairo University, Cairo, Egypt

5. Department of Neurology, Gaziantep City Hospital, Gaziantep, Türkiye

6. Department of Neurology and Clinical Genetics, Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

7. Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea

8. Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei

9. Neurological Institute, Taipei Veterans General Hospital, Taipei

10. Department of Neurology, Tallaght University Hospital / The Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH), Dublin, Ireland

11. Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Gyeonggi-do, Korea

12. Faculty of Medicine, Department of Neurology, Duzce University, Duzce, Turkiye

13. Neurology Center, Neurology and Psychiatric Clinic, West-Tallinn Central Hospital, Tallinn, Estonia

14. Department of Neurology, Danish Headache Center, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark

15. Department of Biophysics, Biomedicine, and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan

16. Headache & Craniofacial Pain Clinic, Department of Neurology, Vall d’Hebron University Hospital, Barcelona, Spain

17. Headache Research Group, Vall d’Hebron Institute of Research, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain

18. Department of Neurology, Mayo Clinic, Phoenix, Arizona, USA

Abstract

Background The term ‘precision medicine’ encompasses strategies to optimize diagnosis and outcome prediction and to tailor treatment for individual patients, in consideration of their unique characteristics. The greater availability of multifaceted datasets and strategies to model such data have made precision medicine increasingly possible in recent years. Precision medicine is especially needed in the migraine field since the response to migraine treatments is not universal amongst all individuals with migraine. Objective To provide a narrative review describing contributions to achieving precision medicine for migraine treatment. Methods A search of PubMed for English language articles of human participants published from 2005 to January 2024 was conducted to identify articles that reported research contributing to precision medicine for migraine treatment. The published literature was categorized and summarized according to the type of data that were included: clinical phenotypes, genomics, proteomics, physiologic measures, and brain imaging. Results Published studies have investigated characteristics associated with acute and preventive treatment responses, such as nonsteroidal anti-inflammatory drugs, triptans, onabotulinumtoxinA, and anti-calcitonin gene-related peptide monoclonal antibodies, in patients with episodic or chronic migraine. There is evidence that clinical, genetic, epigenetic, proteomic, physiologic, and brain imaging features might associate with migraine treatment outcomes, although inconsistencies for such findings clearly exist. Conclusions The published literature suggests that there are clinical and biological features which associate with, and might be useful for predicting, migraine treatment responses. To achieve precision medicine for migraine treatment, further research is needed that validates and expands on existing findings and tests the accuracy and value of migraine treatment prediction models in clinical settings.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/03331024241281518

Reference89 articles.

1. Precision medicine: A new paradigm in therapeutics

2. Stone A. Precision medicine: health care tailored to you. The White House Blog, 2016. https://obamawhitehouse.archives.gov/blog/2016/02/25/precision-medicine-health-care-tailored- you

3. Will precision medicine be available for all patients in the near future?

4. New Approaches to Shifting the Migraine Treatment Paradigm