Cluster headache responsive to indomethacin: Case reports and a critical review of the literature

Author:

Prakash Sanjay1,Shah Nilima D2,Chavda Bhavna V3

Affiliation:

1. Department of Neurology, Medical College Baroda, Gujarat, India.

2. Department of Psychiatry, Medical College Baroda, Gujarat, India.

3. Department of Medicine, Medical College Baroda, Gujarat, India.

Abstract

Introduction: Response to indomethacin is an essential feature for the diagnosis of both paroxysmal hemicrania (PH) and hemicrania continua (HC). Cluster headache (CH) is widely considered to be a disease unresponsive to indomethacin. Case reports: We report four patients with CH who responded to indomethacin. Two patients, who were refractory to the usual therapy for CH, fulfilled the criteria for chronic CH. Conversely, two patients had a history of episodic CH and showed response to both indomethacin and the usual therapy for CH. Literature review: We also reviewed the literature for the presence of indomethacin response in patients with CH. We noted a large number of cases labeled as CH by the authors which showed a response to indomethacin. Discussion: Many cases of definite or possible CH were wrongly labeled as PH because of patients' responding to indomethacin. Conclusion: The response to indomethacin in patients with CH may not be as immediate as in other indomethacin-responsive headaches, and many patients may need larger doses.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Medicine

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