Non-aura visual disturbance with high visual aura rating scale scores has stronger association with migraine chronification than typical aura

Author:

Tsao Yu-Chien123,Wang Yen-Feng345ORCID,Fuh Jong-Ling345,Chen Wei-Ta1345,Lai Kuan-Lin345ORCID,Liu Hung-Yu345,Wang Shuu-Jiun345ORCID,Chen Shih-Pin23456ORCID

Affiliation:

1. Keelung Hospital of the Ministry of Health and Welfare, Keelung, Taiwan

2. Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

3. School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

4. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan

5. Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan

6. Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan

Abstract

Objectives To investigate the clinical correlates of visual symptoms in patients with migraine. Method Patients with migraine that attended our headache clinics were enrolled. Headache profiles, disability, and comorbidities were acquired with structured questionnaires. A semi-structured visual phenomenon questionnaire was also used to assess the characteristics of visual symptoms, including visual aura in patients with migraine with aura and transient visual disturbance in patients with migraine without aura. Headache specialists interviewed with the participants for the ascertainment of diagnosis and verification of the questionnaires. Result Migraine with aura patients with visual aura (n = 743, female/male = 2.3, mean age: 34.7 ± 12.2 years) and migraine without aura patients with non-aura transient visual disturbance (n = 1,808, female/male = 4.4, mean age: 39.4 ± 12.6 years) were enrolled. Patients with transient visual disturbance had higher headache-related disability and more psychiatric comorbidities. Chronic migraine was more common in migraine without aura than migraine with aura patients (41.9% vs. 11.8%, OR = 5.48 [95% CI: 4.33–7.02], p < 0.001). The associations remained after adjusting confounding factors. Conclusion Presence of non-aura transient visual disturbance may suggest a higher migraine-related disability and is linked to higher risk of chronic migraine than typical migraine aura in migraine patients. Further studies are needed to elucidate the potential mechanism.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Medicine

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