Candidate-gene association study searching for genetic factors involved in migraine chronification-Reference-Cited by-同舟云学术

Candidate-gene association study searching for genetic factors involved in migraine chronification

Published:2014-08-28 Issue:6 Volume:35 Page:500-507
ISSN:0333-1024
Container-title:Cephalalgia
language:en
Short-container-title:Cephalalgia

Author:

Louter MA¹²,Fernandez-Morales J³,de Vries B⁴,Winsvold B⁵⁶⁷⁸,Anttila V⁹¹⁰¹¹,Fernandez-Cadenas I¹²¹³,Vila-Pueyo M¹⁴,Sintas C¹⁵¹⁶,van Duijn CM¹⁷,Cormand B¹⁵¹⁶¹⁸,Álvarez-Sabin J¹⁹,Montaner J¹³¹⁹,Ferrari MD¹,van den Maagdenberg AMJM¹⁴,Palotie A⁵⁹¹⁰¹¹,Zwart JA⁶⁷⁸,Macaya A¹⁴,Terwindt GM¹,Pozo-Rosich P³¹⁹

Affiliation:

1. Department of Neurology, Leiden University Medical Center (LUMC), the Netherlands

2. Department of Psychiatry, Leiden University Medical Center (LUMC), the Netherlands

3. Headache and Neurological Pain Research Group, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona

4. Department of Human Genetics, Leiden University Medical Center (LUMC), the Netherlands

5. Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, United Kingdom

6. FORMI, Oslo University Hospital, Norway

7. Department of Neurology, Oslo University Hospital, Norway

8. Institute of Clinical Medicine, University of Oslo, Norway

9. Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, USA

10. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA

11. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

12. Stroke Genetics and Pharmacogenetics, Fundació per la Docència i Recerca Mutua Terrassa, Spain

13. Neurovascular Research Laboratory, Vall d’Hebron Institute of Research, Universidad Autonoma de Barcelona, Spain

14. Pediatric Neurology Research Group, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Spain

15. Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain

16. Centre for Biomedical Network Research on Rare Diseases (CIBERER), Spain

17. Department of Epidemiology, Erasmus University Medical Center, the Netherlands

18. Institute of Biomedicine of the University of Barcelona (IBUB), Spain

19. Neurology Department, Hospital Universitari Vall d’Hebron (HUVH), Spain

Abstract

Introduction Chronic migraine (CM) is at the severe end of the clinical migraine spectrum, but its genetic background is unknown. Our study searched for evidence that genetic factors are involved in the chronification process. Methods We initially selected 144 single-nucleotide polymorphisms (SNPs) from 48 candidate genes, which we tested for association in two stages: The first stage encompassed 262 CM patients, the second investigated 226 patients with high-frequency migraine (HFM). Subsequently, SNPs with p values < 0.05 were forwarded to the replication stage containing 531 patients with CM or HFM. Results Eight SNPs were significantly associated with CM and HFM in the two-stage phase. None survived replication in the third stage. Discussion We present the first comprehensive genetic association study for migraine chronification. There were no significant findings. Future studies may benefit from larger, genome-wide data sets or should use other genetic approaches to identify genetic factors involved in migraine chronification.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0333102414547141

Reference42 articles.

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