Comparison of self-reported cutaneous allodynia and brushing allodynia during migraine attacks

Abstract

This study compares the results of brushing allodynia (BA) during migraine attacks to those of self-reported cutaneous allodynia. We recruited 100 patients (20 with chronic migraine, 80 with episodic migraine) and performed a gauze-brushing test to detect BA. A previous experience of cutaneous allodynia was queried. Seventeen patients reported having allodynia before, whereas 22 patients exhibited BA. The frequency of self-reported allodynia (12.5% vs. 35.0%, p = .040) but not BA (21.3% vs. 25.0%, p = .765) differed between patients with episodic migraine and those chronic migraine. Patients with aura ( N = 8) had a higher frequency of both self-reported allodynia (62.5% vs. 12.2%, p = .003) and BA (87.5% vs. 17.6%, p < .001) than those without aura ( N = 92). Some allodynia symptoms, including avoidance of washing hair, touching the head, combing hair and lying on the site of head pain, were associated with BA (all p < .05). Our study showed that BA during migraine attacks correlated well with prior allodynia symptoms. The frequencies of BA and self-reported allodynia depend on the composition of different migraine subtypes and the timing of the gauze-brushing test.