How migraine and its associated treatment impact on pregnancy outcomes: Umbrella review with updated systematic review and meta-analysis

Author:

Phillips Katherine1ORCID,Clerkin-Oliver Conor2,Nirantharakumar Krishnarajah13,Crowe Francesca L1,Wakerley Benjamin R45

Affiliation:

1. Institute of Applied Health Research, University of Birmingham, Birmingham, UK

2. Cognition Health, Birmingham, UK

3. Midlands Health Data Research UK, University of Birmingham, Birmingham, UK

4. Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

5. University Hospital Birmingham, Birmingham, UK

Abstract

Background Migraine is common in reproductive aged women. Understanding the impact of migraine and associated treatments on pregnancy outcomes remains very important. An umbrella review of systematic reviews, with or without meta-analyses, examined the link between migraine and pregnancy outcomes. Methods We systematically searched Medline, Embase and Cochrane to 27 October 2022. Quality appraisal was carried out using the AMSTAR2 tool. An established framework was used to determine whether included reviews were eligible for update. Results Four studies met review criteria. Migraine was reported to be associated with increased odds ratio (OR) of pre-eclampsia, low birth weight and peripartum mental illness (pooled OR = 3.54 (2.24–5.59)). Triptan-exposed women had increased odds of miscarriage compared to women without migraine (pooled OR = 3.54 (2.24–5.59)). In updated meta-analyses, migraine was associated with an increased odds of pre-eclampsia and preterm birth (pooled OR = 2.05 (1.47–2.84) and 1.26 (1.21–1.32) respectively). Conclusions Migraine is associated with increased odds of pre-eclampsia, peripartum mental illness and preterm birth. Further investigation of the relationship between migraine and placental abruption, low birth weight and small for gestational age is warranted, as well as the relationship between migraine, triptans and miscarriage risk. Systematic Review Registration: Prospero CRD42022357630

Publisher

SAGE Publications

Subject

Neurology (clinical),General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3