Reactive amyloidosis associated with ischial callosititis

Author:

Liu David X.12,Gilbert Margaret H.12,Wang Xiaolei12,Didier Peter J.12,Veazey Ronald S.12

Affiliation:

1. Division of Comparative Pathology (Liu, Didier, Wang, Veazey), Tulane National Primate Research Center, Covington, LA

2. Division of Veterinary Medicine (Gilbert), Tulane National Primate Research Center, Covington, LA

Abstract

Ischial callosities have received little attention in veterinary medicine even though they are distinguishing anatomic organs. The organs are characterized by a pair of hairless pads of thickened epidermis, located bilaterally in the gluteal region, which overlay the tuberosities of the ischia of all Old World monkeys, gibbons, and siamangs. The current report describes a case of reactive amyloidosis associated with ischial callosititis in a rhesus macaque ( Macaca mulatta). Amyloid A (AA) protein was found in the liver, spleen, small intestine, mesenteric lymph nodes, and ischial callosities by histology, Congo red stain, and immunohistochemistry. Confocal microscopy showed that many cluster of differentiation (CD)68-positive macrophages within the ischial callosities contained intracellular AA protein, which suggests that CD68-positive macrophages have an important role in the pathogenesis of reactive amyloidosis in nonhuman primates. The normal histology of ischial callosities of rhesus macaques is also documented in this report.

Publisher

SAGE Publications

Subject

General Veterinary

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The integumentary system of the non-human primate;Spontaneous Pathology of the Laboratory Non-Human Primate;2023

2. Nonhuman Primates;Laboratory Animal Medicine;2015

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