Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes-Reference-Cited by-同舟云学术

Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes

Published:2018-07-20 Issue:5 Volume:30 Page:733-738
ISSN:1040-6387
Container-title:Journal of Veterinary Diagnostic Investigation
language:en
Short-container-title:J VET Diagn Invest

Author:

Canadas Ana¹²³⁴⁵,Santos Marta¹²³⁴⁵,Nogueira Augusto¹²³⁴⁵,Assis Joana¹²³⁴⁵,Gomes Mónica¹²³⁴⁵,Lemos Carolina¹²³⁴⁵,Medeiros Rui¹²³⁴⁵,Dias-Pereira Patrícia¹²³⁴⁵

Affiliation:

1. Instituto de Ciências Biomédicas de Abel Salazar–Universidade do Porto (ICBAS-UP), Porto, Portugal (Canadas, Santos, Lemos, Dias-Pereira)

2. Molecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology of Porto (IPO Porto) Research Center (CI-IPOP), Porto, Portugal (Nogueira, Assis, Gomes, Medeiros)

3. i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal (Lemos)

4. UnIGENe, Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal (Lemos)

5. CEBIMED, Faculty of Health Sciences of Fernando Pessoa University, Porto, Portugal (Medeiros)

Abstract

Cancer is a complex disease involving genetic and phenotypic changes. Several single nucleotide polymorphisms (SNPs) have been associated with the risk of breast cancer development in women; however, little is known regarding their influence on canine mammary tumor risk. We assessed the influence of SNPs in genes related to human breast cancer susceptibility, with respect to the risk of development of mammary tumors in dogs. Sixty-seven canine SNPs in proto-oncogenes, tumor suppressor genes, genes involved in DNA repair, and in hormonal metabolism were evaluated in 212 bitches with mammary tumors and in 161 bitches free of mammary neoplasia. A significant association with mammary neoplasia risk was identified for 2 SNPs in RAD51 ( rs23623251 and rs23642734) and one SNP in the STK11 gene ( rs22928814). None of the other SNPs were related to the risk of mammary tumor development. The identification of genetic profiles associated with risk of mammary neoplasia is of great importance, supporting the implementation of specific clinical management strategies in high-risk animals.

Funder

Research Center of the Portuguese Institute of Oncology of Porto, Portugal

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/1040638718789231

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