Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog

Author:

Clarke Lorelei L.1,Kelly Lisa S.1,Garner Bridget1,Brown Cathy A.1

Affiliation:

1. Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA

Abstract

A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in the lung, spleen, and adrenal glands. Additionally, there was a Chiari-like malformation of the skull with corresponding syringomyelia of the cranial spinal cord. Histologically, the neoplasm was comprised of a pleomorphic population of round cells with a high mitotic rate. Cells stained positive for vimentin and CD18 and negative for cytokeratin, chromogranin A, CD3, CD20, MHC II, and CD11d, and hence the tumor was diagnosed as a histiocytic sarcoma. The cytologic presentation in this case is uncommon for this type of tumor, as was the clinical presentation.

Publisher

SAGE Publications

Subject

General Veterinary

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