CD3-CD20–positive nodal lymphoma with cross-lineage rearrangement in a dog-Reference-Cited by-同舟云学术

CD3-CD20–positive nodal lymphoma with cross-lineage rearrangement in a dog

Published:2020-10-01 Issue:6 Volume:32 Page:964-967
ISSN:1040-6387
Container-title:Journal of Veterinary Diagnostic Investigation
language:en
Short-container-title:J VET Diagn Invest

Author:

Nicoletti Arturo¹^ORCID,Aresu Luca¹,Marino Michele²^ORCID,Massaro Maria²,Martignani Eugenio¹,Caporali Elisa³,Capuccini Silvia³,Bonfanti Ugo²,Gola Cecilia¹

Affiliation:

1. School of Agriculture and Veterinary Medicine, University of Turin, Grugliasco, Turin, Italy

2. Laboratorio La Vallonea, Passirana di Rho, Milano, Italy

3. Clinica Veterinaria San Rocco, Foiana della Chiana, Arezzo, Italy

Abstract

A 7-y-old mixed-breed male dog was presented with a history of generalized lymphadenopathy. Fine-needle aspirates of the enlarged peripheral lymph nodes were suggestive of lymphoma. Histologic examination of a retromandibular lymph node was suggestive of high-grade, medium large-cell lymphoma. Immunohistochemistry revealed concurrent expression of CD3 and CD20. The co-localization of the 2 antigens was confirmed by immunofluorescence. PCR for antigen receptor gene rearrangements (PARR) detected clonal rearrangements for both T-cell receptor gamma and B-cell receptor. The final diagnosis was CD3-CD20–positive anaplastic lymphoma with cross-lineage rearrangement.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/1040638720963132

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