Immunoglobulin G2 Deficiency with Transient Hypogammaglobulinemia and Chronic Respiratory Disease in a 6-Month-Old Holstein Heifer-Reference-Cited by-同舟云学术

Immunoglobulin G2 Deficiency with Transient Hypogammaglobulinemia and Chronic Respiratory Disease in a 6-Month-Old Holstein Heifer

Published:2004-09 Issue:5 Volume:16 Page:432-435
ISSN:1040-6387
Container-title:Journal of Veterinary Diagnostic Investigation
language:en
Short-container-title:J VET Diagn Invest

Author:

Francoz David¹,Lapointe Jean-Martin²,Wellemans Vincent²,Desrochers André¹,Caswell Jeff L.³,Stott Jeff L.⁴,Dubreuil Pascal¹

Affiliation:

1. Département des Sciences Cliniques, Case postale 5000, Saint Hyacinthe, Québec, Canada J2S 7C6

2. Département de Pathologie et Microbiologie, Case postale 5000, Saint Hyacinthe, Québec, Canada J2S 7C6

3. Faculté de Médecine Vétérinaire, Université de Montréal, Case postale 5000, Saint Hyacinthe, Québec, Canada J2S 7C6, the Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1

4. Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616.

Abstract

A 6-month-old Holstein heifer that was nonresponsive to medical treatment was evaluated for chronic respiratory disease. Complete blood count and serum chemistry revealed neutrophilic leukocytosis and low globulin levels. Assays for bovine leukemia virus, bovine virus diarrhea, and bovine leukocyte adhesion deficiency were negative. Serum globulin subclass assays revealed transient low concentrations of immunoglobulin (Ig) G1 and IgA, persistent low IgG2, and subnormal IgM. Vaccination with 2 doses of multiple, inactived viruses induced seroconversion for most viruses. Flow cytometric analysis of blood lymphocyte subpopulation demonstrated an increase in CD5+ B-cells. Blood lymphocyte proliferation and neutrophil function tests were normal. Results of immunologic assays indicated IgG2 deficiency with transient hypogammaglobulinemia.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/104063870401600511

Reference30 articles.

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