Alpha-Fetoprotein in Serum and Tumor Tissues in Dogs with Hepatocellular Carcinoma-Reference-Cited by-同舟云学术

Alpha-Fetoprotein in Serum and Tumor Tissues in Dogs with Hepatocellular Carcinoma

Published:2006-05 Issue:3 Volume:18 Page:291-295
ISSN:1040-6387
Container-title:Journal of Veterinary Diagnostic Investigation
language:en
Short-container-title:J VET Diagn Invest

Author:

Kitao Satoshi¹,Yamada Takatsugu²,Ishikawa Takefumi²,Madarame Hiroo³,Furuichi Mitsuru²,Neo Sakurako²,Tsuchiya Ryo²,Kobayashi Kosaku²

Affiliation:

1. Laboratory of Veterinary Internal Medicine, 1-6-45 Nakahozumi, Ibaraki, Osaka, Japan 567-0034

2. Dobutsu Medical Center, 1-6-45 Nakahozumi, Ibaraki, Osaka, Japan 567-0034

3. Veterinary Teaching Hospital, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara-shi, Kanagawa 229-8501, Japan

Abstract

Serum alpha-fetoprotein (AFP) concentrations were measured before and after surgical removal of tumor masses in four dogs with hepatocellular carcinoma (HCC). Localization of AFP was also examined immunohistochemically in tumor tissues. In three cases, the serum AFP concentration was 10 to 20 times higher than that of normal dogs. One to two months after surgery, the serum AFP concentration had decreased to normal range. AFP was localized in the tumor tissues in these three cases. One case, which had a low serum AFP, did not show AFP localization in tumor tissue.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/104063870601800312

Reference13 articles.

1. Cellular aspects of alpha-fetoprotein reexpression in tumors

2. Alpha1Fetoglobulin in the Diagnosis of Human Hepatoma

3. α1-Fetoprotein production during the hepatocyte growth cycle of developing rat liver

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