Paratuberculosis in a Mandrill (Papio Sphinx)

Author:

Zwick Laura S.1,Walsh Timothy F.2,Barbiers Robyn3,Collins Michael T.4,Kinsel Michael J.1,Murnane Robert D.1

Affiliation:

1. Zoological Pathology Program, University of Illinois College of Veterinary Medicine, Loyola University Medical Center, Room 0745, Building 101, 2160 South First Avenue, Maywood, IL 60153

2. Washington State University, College of Veterinary Medicine, Pullman, WA 99164–7012

3. Lincoln Park Zoological Gardens, 2001 North Clark Street, Chicago, IL 60614

4. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706–1102

Abstract

A 2.5-year-old captive female mandrill ( Papio sphinx) died following a protracted course of intermittent abdominal bloat, diarrhea, and severe weight loss. Necropsy revealed emaciation and marked gastrointestinal distention with gas and ingesta. Histologic evaluation revealed severe diffuse granulomatous enterocolitis and mesenteric lymphadenitis with massive numbers of 1–2-μm acid-fast bacilli within macrophages. Additionally, there was moderate to severe multifocal myocardial and vascular amyloidosis, moderate multifocal pyogranulomatous interstitial pneumonia with no acid-fast bacteria, and moderate multifocal glossal candidiasis. Samples of feces, ileum, and colon were positive for Mycobacterium avium subsp. paratuberculosis by radiometric culture and a polymerase chain reaction-amplified DNA probe specific for the insertion sequence IS900 of this organism.

Publisher

SAGE Publications

Subject

General Veterinary

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