Reproduction of Postweaning Multisystemic Wasting Syndrome in Pigs Experimentally Inoculated with a Swedish Porcine Circovirus 2 Isolate-Reference-Cited by-同舟云学术

Reproduction of Postweaning Multisystemic Wasting Syndrome in Pigs Experimentally Inoculated with a Swedish Porcine Circovirus 2 Isolate

Published:2003-11 Issue:6 Volume:15 Page:553-560
ISSN:1040-6387
Container-title:Journal of Veterinary Diagnostic Investigation
language:en
Short-container-title:J VET Diagn Invest

Author:

Allan Gordon¹,McNeilly Francis¹,Meehan Brian²,McNair Irene¹,Ellis John³,Krakowka Steve⁴,Fossum Caroline⁵,Wattrang Eva⁵,Wallgren Per⁶,Adair Brian¹

Affiliation:

1. Veterinary Sciences Division, Department of Agriculture and Rural Development, Belfast BT4 3SD, Northern Ireland, UK

2. Department of Veterinary Science, Queen's University Belfast, Belfast BT4 3SD, Northern Ireland, UK

3. Department of Veterinary Microbiology, University of Saskatchewan, Saskatchewan 57N 5B4, Canada

4. College of Veterinary Medicine, Ohio State University, Columbus, Ohio 43210

5. Division of Immunology, Department of Veterinary Microbiology, Uppsala, Sweden

6. National Veterinary Institute, SE-751 89 Uppsala, Sweden

Abstract

In recent years, porcine circovirus type 2 (PCV2)—associated postweaning multisystemic wasting syndrome (PMWS) has been reported worldwide. However, to date, PMWS has not been reported in Sweden despite the demonstration of serum antibodies to a PCV2-like virus in Swedish pigs. This communication reports the experimental reproduction of clinical PMWS after inoculation of colostrum-deprived (CD) pigs, derived from a Northern Ireland herd, with an isolate of PCV2 virus recovered from a clinically normal Swedish pig that was necropsied in 1993. The clinical disease and histological lesions observed in CD pigs inoculated with this virus were indistinguishable from those observed in previous studies on CD pigs inoculated with a PCV2 virus isolate recovered from pigs with PMWS. These results highlight the disease potential of PCV2 isolated from regions apparently free of PMWS and suggest that the status of the host and its environment is an important factor in the development of clinical PMWS.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/104063870301500607

Reference17 articles.

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4. Postweaning Multisystemic Wasting Syndrome Induced after Experimental Inoculation of Cesarean-Derived, Colostrum-Deprived Piglets with Type 2 Porcine Circovirus

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