A High-Performance Liquid Chromatography Method for Determination of 4-Aminopyridine in Tissues and Urine-Reference-Cited by-同舟云学术

A High-Performance Liquid Chromatography Method for Determination of 4-Aminopyridine in Tissues and Urine

Published:1990-04 Issue:2 Volume:2 Page:132-134
ISSN:1040-6387
Container-title:Journal of Veterinary Diagnostic Investigation
language:en
Short-container-title:J VET Diagn Invest

Author:

Casteel Stan W.¹,Thomas Brian R.²

Affiliation:

1. Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65205

2. Kerr-McGee Chemical Corp., PO Box 478, Soda Springs, ID 83276

Abstract

An analytical method was developed to measure 4-aminopyridine in tissues and urine to determine appropriate diagnostic samples in acute poisoning cases. Tissues from rats dosed with 4-aminopyridine were extracted with methylene chloride. Extracts were analyzed by high-performance liquid chromatography using an isocratic solvent system of acetonitrile and aqueous solution (15/85 v/v) consisting of 0.015 M sodium salt of 1-heptane-sulfonic acid, 0.002 M tetramethylammonium bromide, and 0.01 M sodium dihydrogen phosphate adjusted to pH 3.0 with phosphoric acid. We concluded that suitable diagnostic samples for acute poisoning cases include stomach contents, kidney, liver, and urine.

Publisher

SAGE Publications

Subject

General Veterinary

Link

http://journals.sagepub.com/doi/pdf/10.1177/104063879000200210

Reference10 articles.

1. PHARMACOKINETICS OF 4-AMINOPYRIDINE IN HUMAN VOLUNTEERS

2. A microanalytical method for 4-aminopyridine in sunflower seeds and plants

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