Gender-specific Effects of Calcitonin Gene-related Peptide and Substance P on Coronary Blood Flow in an Experimental Model

Author:

Hongbao Ma12,Yan Yang2,Shen Cherng3

Affiliation:

1. Bioengineering Department Zhengzhou University, Zhengzhou, Henan, China

2. Brookdale University Hospital and Medical Center, Brooklyn, New York

3. Department of Electrical Engineering, Chengshiu University, Niaosong, Taiwan, China.

Abstract

Background Calcitonin gene-related peptide (CGRP) and substance P (SP) play counter-regulatory roles in coronary flow. This study is to assess whether effects of CGRP and SP are gender-specific. Methods Langendorff-perfused hearts were used to compare coronary flow rates among 119 wild-type, α-CGRP and SP receptor knockout mice under various perfusion pressures (20, 30, 40, 50 mmHg). Results For mouse heart coronary flow rate, deletion of α-CGRP gene resulted in significant reduction for both genders at all pressures; female CGRP knockout showed 15.3% reduction ( P < .01); male CGRP knockout showed 13.8% reduction ( P < .01); no significant difference between male and female CGRP knockout; female SP receptor knockout showed 13.9% increase ( P < .01); female SP receptor knockout had a greater percentage decrease than male ( P < .01). Conclusions CGRP plays similar roles as a vasodilator in males and females. SP seems to act as a vasoconstrictor in females.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3