Higher Recurrence Rate After Coronary Angioplasty in Unstable Angina Pectoris

Abstract

Purpose: Recurrent stenosis after percutaneous transluminal coronary an gioplasty (PTCA) is a significant problem, requiring repeat dilation in about one-third of all treated patients. Various clinical and procedure-related predic tors have been proposed. Between 1983 and 1987, 257 patients underwent 322 procedures, where 380 stenoses were attempted. Indications were: stable angina pectoris 73 %, unstable angina pectoris 22 %, other indication 5%. The primary success rate was defined as a <50% remaining postprocedure stenosis. Findings: Repeat angiograms were done for 88 % of the initially successful cases, either six months after PTCA or if there was a clinical recurrence. Restenosis was defined as a recurrence of a more than 50% diameter stenosis. The restenosis rate was 33 % and was significantly higher (p<0.05) for unstable (46 % ) than for stable angina pectoris (29%). There was a nonsignificant tendency to a higher restenosis rate in the left anterior descending artery than in the other coronary vessels. Implications: The increased restenosis rate seen after PTCA for unstable angina pectoris could be caused by a higher activity in systems affecting the proliferative processes in the smooth muscle cells of the arterial wall, which is thought to form the pathophysiologic basis for restenosis after PTCA.