Minoxidil in the Treatment of Refractory Hypertension

Abstract

Minoxidil, a powerful vasodilator, is a very effective antihypertensive drug. Twenty-two patients, who were mostly refractory to conventional anti hypertensive medication, were treated with this drug. There was a swift and definite drop of blood pressure in all cases. In 7 patients with renal disease, renal function did not deteriorate during the administration of minoxidil, and it improved dramatically in the eighth patient. Side effects of the drug were hir sutism, fluid retention, and in 1 patient a pruritic bullous erruption which dis appeared when the drug was discontinued.