Affiliation:
1. Department of Medicine University Hospital CH-8091 Zurich, Switzerland
Abstract
In an overview the microvascular involvement in chronic venous insufficiency (CVI) is described. Microangiopathy in the lower leg areas is characterized by the presence of typical enlarged and ramified blood capillaries, reduced capillary number, microvascular thrombosis and obliterations, and/or increased permeability of microlymphatics. Transcutaneous oxygen tension (tcPO2) is decreased and directly correlated to the number of perfused capillaries, whereas laser Doppler flux is enhanced. This apparent paradox may be explained by hyperperfusion in the deeper skin layers (mainly shunt vessels) and hypoperfusion in the superficial nutritive vessels. Microvascular changes are of patchy distribution. Trophic changes up to overt venous ulceration are mainly caused by microvascular ischemia and edema formation due to increased capillary permeability and deficient lymphatic drainage.
Subject
Cardiology and Cardiovascular Medicine
Reference31 articles.
1. Arnoldi CC: Physiology and pathophysiology of the venous pump of the calf. In: Controversies in the Management of Venous Disorders, ed. by Eklöf B, Thulesius O, Bergqvist D. London: Butterworth, 1989, pp 6-23.
2. Local Microcirculation in Chronic Venous Incompetence and Leg Ulcers
3. Microangiopathy in Severe Chronic Venous Insufficiency Evaluated by Fluorescence Video-Microscopy
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