Can Statins Suppress the Development of Abdominal Aortic Aneurysms? A Review of the Current Evidence-Reference-Cited by-同舟云学术

Can Statins Suppress the Development of Abdominal Aortic Aneurysms? A Review of the Current Evidence

Published:2009-07-21 Issue:2 Volume:61 Page:137-144
ISSN:0003-3197
Container-title:Angiology
language:en
Short-container-title:Angiology

Author:

Saratzis Athanasios¹,Kitas George D.²,Saratzis Nikolaos³,Melas Nikolaos³

Affiliation:

1. 1st Department of General Surgery and Vascular Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece, a_saratzis@ yahoo.gr

2. Department of Rheumatology, Russells Hall Hospital, Dudley, United Kingdom

3. 1st Department of General Surgery and Vascular Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece

Abstract

Statins possess several pleiotropic effects and have been shown in vitro and in vivo to inhibit the expression of inflammatory mediators and downregulate molecules involved in extracellular matrix (ECM) degradation. Recent observational studies in humans suggest that statins may have a role in abdominal aortic aneurysm (AAA) prevention or may even inhibit aneurysm expansion. In this review, we summarize the effects of statins on the vessel wall of aneurysmal aortas and currently available data concerning their inhibitory effects on aneurysm progression.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003319709335514

Reference61 articles.

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